The Zoloft MDL is going to have to pick up its pace if it's going to usher the way for state courts that are hearing similar cases, the federal judge presiding over the case told a room full of attorneys in federal court in Philadelphia during a status conference Thursday.

The multidistrict litigation, which was consolidated in the court of U.S. District Judge Cynthia Rufe of the Eastern District of Pennsylvania in the spring of 2012, now includes about 450 cases in which plaintiffs allege that their ingestion of Pfizer's antidepressant drug, Zoloft, caused birth defects in the babies they were pregnant with while they took the drug.