Lawyers representing researchers, pathologists, and women’s health groups urged a federal appeals court in Washington, D.C., to uphold a ruling that said a genetics company’s patents on two human genes are invalid and unconstitutional.

For more than an hour on April 4, the U.S. Court of Appeals for the Federal Circuit grappled with the case, narrowly assessing whether an isolated gene is substantively different from DNA itself, and more broadly looking at how the resolution of the case has potential consequences for the biotechnology industry.

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