To resolve a spate of whistleblower lawsuits, drug manufacturer Cephalon Inc. of Frazer, Pa., has agreed to pay $431 million in civil and criminal fines for illegally promoting “off-label” uses for three of its drugs, federal prosecutors said.

In a global settlement with the U.S. Justice Department, Cephalon agreed to pay $375 million to settle False Claims Act claims by the Medicaid and Medicare trust funds and to plead guilty to a single misdemeanor criminal charge of distribution of misbranded drugs and pay $50 million in fines and forfeiture.

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