Wednesday’s decisive Supreme Court ruling against Wyeth in a landmark pharmaceutical product liability case also may close off a major front in a hard-fought battle by businesses and the Bush administration to insulate national corporations from state tort litigation.

The high court’s decision is the second blow to attempts to protect drug companies from suits after their activities have won Food and Drug Administration approval. In Georgia last week, a Senate committee rejected Gov. Sonny Perdue’s attempt to provide immunity from product-liability suits to Georgia companies whose products have FDA approval.

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