Drugmaker Bristol-Myers Squibb Co. on Thursday reported double-digit jumps in first-quarter sales and net income, beating Wall Street expectations, but it lowered its 2010 profit forecast by a nickel due to the impact of the health care overhaul.

Still, the maker of blockbuster blood thinner Plavix posted a very healthy improvement in first-quarter profit, which jumped 16.5 percent to $743 million, or 43 cents per share, from $638 million or 32 cents per share, in the first quarter of 2009.