San Francisco’s best-known white-collar defendant says he needs the cooperation of prosecutors to defend himself against charges of securities fraud. The government, unsurprisingly, doesn’t seem to like that idea.

Over the last few weeks, lawyers for Gregory Reyes, the ex-CEO of Brocade Communications — and the first person to be charged in the burgeoning stock option backdating prosecutions — have been frustrated as former company employees have invoked the Fifth Amendment in refusing to be deposed as Reyes prepares to defend SEC civil charges of stock fraud.

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