Move cautiously—that’s the message recently sent by more than 170 business organizations and research groups to the attorney general and acting solicitor general as the government considers its position in the biggest patent case of the Supreme Court term.

In a letter concerning Microsoft v. i4i, the organizations said, “We are greatly concerned that a reversal of the lower court’s decision in this case could seriously weaken the presumption of validity that attaches to millions of patents in force in the United States today, thereby undermining longstanding investment-backed reliance interests that are critical for domestic job creation and economic growth, and for U.S. technological leadership internationally.”