The challenge in finding an impartial jury to decide whether Brian G. Nichols should be held responsible for a 2005 shooting spree for which he stands accused of four murders was apparent on Thursday morning when Judge James G. Bodiford asked the first 16 prospective jurors whether any had formed or expressed an opinion as to Nichols’ guilt: 10 hands shot up immediately.

So it went on Thursday, which ended with Bodiford addressing another challenge to the long-delayed case — the defense’s request not to have the trial at the Fulton County Courthouse, where three of the four killings took place.