In a ruling that could be the last straw for the long-running litigation over acne drug Accutane, a New Jersey appeals court has barred testimony from two experts linking the drug to ulcerative colitis.

The appeals court upheld a 2017 ruling by Superior Court Judge Nelson Johnson barring expert opinions from gastroenterologist David Sachar and epidemiologist April Zambelli-Weiner. Those expert opinions incorporated the same type of “methodological defects” identified by the New Jersey Supreme Court in a landmark 2018 ruling that excluded two other plaintiffs’ experts who linked Accutane to Crohn’s disease, the appeals court said.

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