SAN FRANCISCO — In one of the largest cuts of this layoff season to date, Orrick, Herrington & Sutcliffe sent home 12 percent of its nonpartner lawyers on Tuesday.

Worldwide, the firm cut 100 associates and of counsel from a total of 807, and 200 staff. Half of those affected are in the United States, the firm reported, while a quarter each are in Asia and Europe. A firm spokesman said no partners were let go.