A federal district judge in Virginia on Monday hit Abbott Laboratories with the second-largest criminal fine for a single drug.

The pharmaceutical company was ordered by U.S. District Judge Samuel Wilson of the Western District of Virginia to pay a criminal fine amount of $500 million, a forfeiture of $198.5 million, and $1.5 million to the Virginia Medicaid Fraud Control Unit for marketing the drug Depakote for uses not approved as safe and effective by the U.S. Food and Drug Administration.