In the hours after U.S. Supreme Court Justice Anthony Kennedy announced his retirement, conservative groups immediately began to marshal pro-life women to talk about potential replacements in the context of overturning Roe v. Wade.

The issue of abortion is likely to define the fight to fill Kennedy’s vacancy for many on both the left and the right. A source involved in the effort to confirm Justice Neil Gorsuch in 2017 said anti-abortion spokeswomen would be seen leading the charge for whatever candidate the president puts forward.