Plaintiffs have not met their burden of establishing the reliability and admissibility of the opinions of one of their experts in multidistrict litigation over whether the antidepressant Zoloft causes birth defects, Pfizer Inc. said in court papers.

The briefing has gone through three rounds on the admissibility of Anick Bérard’s testimony, starting with Pfizer’s motion to exclude the proposed expert, with the plaintiffs’ response and now with the drugmaker’s response. Bérard is a perinatal epidemiologist who studies babies’ exposure to drugs before they are born.