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Corporations interested in enforcing their intellectual property, monetizing their patent portfolios, or defending themselves against charges of infringement have multiple forums to press their case, the most popular of which are: an infringement suit or declaratory judgment action in the United States district courts; an investigation at the U.S. International Trade Commission (ITC), and filing either an inter partes review or post-grant review at the U.S. Patent and Trademark Office. Each forum has unique opportunities and challenges, and it can be hard to determine the benefits and drawbacks of each. This series introduces each venue and the strategic considerations in pursuing actions at each, starting with the district courts.