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In a somewhat rare reversal of an obviousness decision by the Board of Patent Appeals and Interferences, the Federal Circuit’s recent decision in Leo Pharmaceutical Products, Ltd. v. Rea provides important guidance in navigating the post-KSR landscape. In applying a common-sense evaluation of the facts, the court placed great emphasis on the passage of time between the asserted prior art and the claimed invention, which it found “sp[oke] volumes” against obviousness. The court also highlighted the importance of considering whether the prior art disclosed the problem solved by the inventors, and reminded litigants that objective indicia of nonobviousness must be more than a mere “afterthought” in an obviousness analysis.