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Over the last generation research and development has become truly global. Scientists in London are collaborating in the course of a single business day with counterparts in Guanzhou, Bangalore, Stuttgart, Sao Paulo and Sunnyvale. Together these scientists generate brilliant new ideas that lead to wonderful new products and services and, of course, patent filings—in at least some of the countries in which collaboration is taking place and frequently in many other countries. And that is where the neat modern system of global R&D ceases to be neat, modern or global. At the intersection of patent and national security law there is a conundrum affecting anyone relying on global research and development: where to file an initial patent application for an invention derived from multinational resources? This question deserves serious consideration by any entity engaged in cross-border invention.