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It’s an exciting but edgy time to be handling intellectual property for a biotechnology enterprise. These companies are searching for cures for cancer, vaccines to eradicate disease, and ways to help relieve the suffering caused by AIDS. As a scientific and business proposition, it doesn’t get much more exciting. These companies are also edgy, in both a legal and financial sense. They’re exploring legal frontiers by patenting gene sequences that critics think should be outside the bounds. Some of them teeter on the financial edge, a deal or a payday away from collapse. And the biotech sector has not escaped the stock market’s recent wrath. Even so, for lawyers who like risk — and they do exist — biotech is a great place to be. There’s room for deal makers, litigators, and patent prosecutors alike. In these profiles, reporters Victoria Slind-Flor, Lisa Shuchman, and Alexandra Dell look at five in-house counsel whose jobs offer plenty of promise and peril. • Diana Hamlet-Cox, Incyte Corp. • Lance Ishimoto, Lexicon Genetics Inc. • Jonathan Klein-Evans, Medimmune Inc. • Victor Lee, Celera Diagnostics • Kenneth Barovsky, Quantum Dots Corp.

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