DannyLee Mitchell knew she would face a rough road physically and emotionally when she decided to transition from a man to a woman. What she didn’t expect was to lose her job and spark a fierce legal battle over the civil rights of transsexual people.

Mitchell had been employed by Axcan Scandipharm, a pharmaceutical and hospital-supply company based in Birmingham, Ala., as a sales representative for four years when, in November 2003, she informed her supervisors that she was a pre-operative transsexual and had been diagnosed with gender identity disorder.