The U.S. Court of Appeals for the Federal Circuit on Friday upheld lower court findings that reject a causal connection between childhood vaccines and the onset of autism.

The ruling came in Cedillo v. Secretary of Health and Human Services, which was the first of a series of test cases heard by special masters for the U.S. Court of Federal Claims in 2007. The claims court picked several such cases to test different theories of causation advanced in the roughly 5,000 cases alleging a link to autism filed under the National Childhood Vaccine Injury Act of 1986.

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