At least four petitions are pending before the U.S. Court of Appeals for the Sixth Circuit that, if successful, could unravel much of the work done in the opioid lawsuits, including preparations for a trial later this month.

U.S. District Judge Dan Polster of the Northern District of Ohio, who is overseeing more than 2,000 lawsuits in multidistrict litigation over the opioid crisis, has issued several rulings in the past month focused on both a potential global settlement and the Oct. 21 trial. The appellate petitions, brought by a hodgepodge of parties that includes the opioid defendants and the states and cities suing them, ask the Sixth Circuit to review many of Polster’s decisions.

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