In a historic vote, the U.S. House of Representatives on Wednesday approved legislation to shield banks that serve state-licensed cannabis and hemp operators—as well as businesses and insurers that serve those industries—from federal regulators.

The Secure and Fair Enforcement Banking Act passed on a bipartisan 321-103 vote, marking the first time a stand-alone cannabis policy bill advanced from the House. That it passed so overwhelmingly with significant support from Republicans speaks volumes about the seismic shift in public opinion, and politics, surrounding marijuana.