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The America Invents Act (AIA) is poised to make the most significant changes to the examination of U.S. patent applications in more than 50 years. While certain provisions of the AIA became effective in November 2011, the most significant changes to the fundamentals of patentability will not take effect until March 2013. At this point, the U.S. will change from a first-to-invent system to a first-inventor-to-file system.